Eficácia clínica dermocosmética e mecanismos de ação do ácido retinóico e seus derivados na pele: uma breve revisão da literatura

Abstract

Retinoids have been used for decades for skin treatments, especially for their anti- photoaging, anti-acne properties and the reduction of skin hyperpigmentation, being responsible for a variety of effects on the transcription of genes that regulate the growth, differentiation and transformation of epithelial tissue. This literature review lists a series of clinical studies that prove these properties, such as stimulating collagen synthesis, producing elastin fibers, blocking sebocyte cell division and reducing inflammation caused by acne. The studies were carried out mainly on mature skin and different concentrations of active ingredients were tested. Based on the data found in this review, the effectiveness and safety of retinoic acid and its derivatives for dermatological treatments can be proven.