Modelo computacional para analisar o efeito do fingolimod no bloqueio de migração de células T CD8+ na esclerose múltipla

Abstract

Multiple Sclerosis (MS) is a chronic disease of the central nervous system characterized by inflammatory and neurodegenerative processes, leading to demyelination and neuronal impairment. It primarily affects young adults and has no cure, although current treatments can reduce disease progression. This study investigates the impact of Fingolimod, a sphingosine-1-phosphate receptor modulator that reduces lymphocyte migration to the central nervous system, minimizing MS-associated inflammation. The analysis is conducted using cohort data and mathematical modeling, allowing the simulation of the drug’s effects on the immune dynamics of the disease. The results indicate that the model can represent the dynamics related to the migration blockade of CD8+ T cells. It is expected that the findings will contribute to improving therapeutic strategies and aid in developing new approaches for MS treatment.