Síntese, caracterização e avaliação biológica de complexos de vanádio e de ouro com bases de Schiff e benzimidazóis

Abstract

The metal ions and their complexes are present in biological systems exersing important biological functions. However, the use of metal ions and their compounds, it was empirically. Systematic investigation of metals complexes seems to have come only after the studies of Paul Ehrlich and RobertKoch. Diiminics Schiff bases, as well as benzimidazole derivatives, have known biological activities. Some complexes containing vanadium (IV or V) and gold (I or III) also have recognized biological uses. Therefore, complexes involving Schiff Bases diíminicas and benzimidazole metal ions vanadium and gold is a major field of study within the field of Bioinorganic Chemistry. Within this context, this paper deals with the synthesis and characterization of Schiff bases and diimínicas benzimidazole obtained from the condensation between benzaldehyde and 1,2-phenylenediamine or its derivatives. This paper also reports the synthesis, characterization and biological study of complexes involving Schiff bases and diimínicas benzimidazole obtained with ions of vanadium (IV) and gold (I and III). In the end, fourteen compounds are reported, six and eight ligand complexes. Seven of these compounds have not been reported in the literature. The compounds, except IMOH and [AuIIMOMeCl], were tested against the protozoa of the Leishmania promastigote stage, with the species L. amazonesis, L. braziliensis, L. chagasi and L major. The most significant results were found for compounds involving ion AuIII. The AuIII complexes were also tested against the amastigote stage of the parasite species against L. amazonesis, L. braziliensis and L major.