Efeitos anti-inflamatórios da ingestão de cacau em pacientes com síndrome metabólica e distúrbios relacionados: uma revisão sistemática e meta-análise

Abstract

Randomized controlled trials have investigated the potential role of cocoa in modulating inflammatory processes associated with metabolic syndrome, but the effect remains controversial. This meta- analysis aimed to evaluate the impact of cocoa supplementation on inflammatory biomarkers in patients with metabolic syndrome and related disorders. PubMed, Scopus, Web of Science, and Embase were systematically searched until September, 2024. In total, 13 RCTs were included for meta-analysis, including 14 arms. Our findings revealed that cocoa supplementation significantly reduced CRP (-0.08 mg/dL, 95 % CI: -0.16, -0.001 p= 0.0451), while no significant effects were observed on TNF-α (10.96 pg/mL, 95 % CI: -0.16, 0.38; p = 0.4210), or IL-6 (-4.44 pg/mL, 95 % CI: -0.90, 0.01; p= 0.0559). None of these analyses showed heterogeneity between the studies. Overall, this meta-analysis suggests that cocoa intake may lower inflammatory biomarkers concentrations.