Associação entre doenças sistêmicas e ocorrência de doenças fúngicas na cavidade oral em pacientes pediátricos: revisão sistemática

Abstract

Objective: This study conducted a systematic review to identify a possible relationship between systemic diseases and oral fungal infections in children up to 12 years of age. Methods: The review was conducted according to PRISMA guidelines and registered with PROSPERO (CRD42024629745). The search was conducted in PubMed, Web of Science, Embase, Scopus, and Google Scholar databases, using a specific search strategy for each. The selected articles had to meet the inclusion criteria. The Joanna Briggs methodological quality checklist was used according to the study designs that were evaluated. Results: A total of 7313 articles were identified, of which 1987 duplicate records were excluded, resulting in 5326 articles that underwent the title and abstract screening stage. After this stage, 209 remained for full reading and analysis. The final sample consisted of 69 studies. A gray literature search, conducted through the Google Scholar database, did not identify any new documents related to the objective of this study. Data analysis showed that the predominant oral fungal infection was candidiasis, followed by mucormycosis, aspergillosis, and phaeohyphomycosis. HIV + / AIDS, malnutrition, acute lymphoblastic leukemia, and acute myeloid leukemia were the most prevalent systemic diseases among children with oral fungal disease. Conclusion: The interrelationship between systemic diseases and oral fungal infections in the pediatric population up to 12 years of age was identified, given that of the 1511 patients with some form of oral fungal disease, only four were healthy.